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OBJECTIVE To explore the immune protection of the monoclonal antibody (McAb) against Cryptosporidium parvum. METHODS On the basis of Madin-Darby canine kidney (MDCK) cell culture, the immunoprotection of McAb against C. parvum was screened by means of neutralization test in vitro, and verified by rat model and transmission electron microscopy of infected MDCK cells. RESULTS The number of C. parvum sporozoites recovered on the surface of rat intestinal epithelial cells and the mean output of oocyst were significantly reduced by McAb Z3D2 (P < 0.001, P < 0.05). The decreased Cryptos poridium at each development phase within infected MDCK cells and less damage of cell ultrastructure caused by Cryptosporidium were found in Z3D2 treated group. CONCLUSIONS McAb Z3D2 possesses highly effective protection against C. parvum.
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