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Sordaricin antifungal agents. 2003
Claude A Quesnelle, and
Patrice Gill, and
Marco Dodier, and
Denis St Laurent, and
Michael Serrano-Wu, and
Anne Marinier, and
Alain Martel, and
Charles E Mazzucco, and
Terry M Stickle, and
John F Barrett, and
Dolatrai M Vyas, and
Balu N Balasubramanian
Bristol-Myers Squibb Pharmaceutical Research Institute, 100, boul. de l'Industrie, Candiac, Québec, Canada J5R 1J1. claude.quesnelle@bms.com
Compounds based on sordaricin were prepared via organometallic addition onto a fully protected sordaricin aldehyde. The fungal growth inhibition profiles for these compounds were established and the results are presented here. The synthesis of homologated sordaricin as well as ether and ester derivatives is presented, and structural rearrangement products upon oxidation. These compounds were evaluated as agents to inhibit fungal growth.
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