-transparent.png){kind=logo}
Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. 2003
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.
Cimigenol (1) and 39 related compounds were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Structure-activity relationship analysis indicated that compound 1 showed the highest activity and also exhibited significant inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that 1 and the related compounds might be valuable anti-tumor promoters.
Related Publications
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
May 2000,
Cancer letters,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
July 1999,
Cancer letters,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
February 2002,
Cancer letters,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
April 2003,
Cancer letters,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
February 1995,
Biological & pharmaceutical bulletin,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
May 1994,
Biological & pharmaceutical bulletin,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
March 2002,
Cancer letters,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
February 1995,
Biological & pharmaceutical bulletin,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
November 2001,
Cancer letters,
Nobuko Sakurai, and
Mutsuo Kozuka, and
Harukuni Tokuda, and
Yoshitaka Nobukuni, and
Junko Takayasu, and
Hoyoku Nishino, and
Akiko Kusano, and
Genjiro Kusano, and
Masahiro Nagai, and
Yojiro Sakurai, and
Kuo Hsiung Lee
June 2000,
Cancer letters,
