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Sarcoplasmic reticulum (Ca2+ + Mg2+)-ATPase was previously shown to have Ca2+-dependent and -selective ionophoric activity when tested in oxidized cholesterol lipid bilayer membranes (Shamoo, A. E., and MacLennan, D. H. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 3522). ruthenium red, a known inhibitor of (Ca2+ + Mg2+)-ATPase, is found to inhibit the Ca2+-ionophoric activity associated with (Ca2+ + Mg2+)-ATPase. Furthermore, ruthenium red alone acts as an anion-selective ionophore in lipid bilayers with the the following selectivity sequence for anions: l- greater than Cl-, Br- greater than F- greater than NO3-. The PCl-/PNa+ ratio was approximately 4/l. The presence of ruthenium red in excess of Ca2+ ionophore in lipid bilayer experiments converts the cation selectivity of the bilayer due to Ca2+ ionophore into anion selectivity.
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
March 1984,
Journal of biochemistry,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
May 1982,
Journal of biochemistry,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
January 1982,
Zeitschrift fur Naturforschung. Section C, Biosciences,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
January 1985,
Cellular and molecular biology,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
January 1981,
Biochemistry,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
November 1986,
Archives of biochemistry and biophysics,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
December 1980,
The Journal of biological chemistry,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
June 1978,
Canadian journal of biochemistry,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
December 2000,
Naunyn-Schmiedeberg's archives of pharmacology,
A E Shamoo, and
T R Thompson, and
K P Campbell, and
T L Scott, and
D A Goldstein
December 1978,
The Journal of membrane biology,
