OBJECTIVE Investigate whether an ergonomic computer device, characterised by an inclined working area and keyboard localisation close to the screen (the Up-Line), decreases the muscle activity of the upper trapezius muscle. METHODS In a crossover design 19 healthy subjects and 19 patients with Whiplash Associated Disorder (WAD) typed during 10 min at the Up-Line and at a standard workstation with 15 min of rest in between. During typing surface EMG was measured of the trapezius muscle. The subjects were asked to rate sitting comfort and complaints. RESULTS Although most subjects subjectively preferred the Up-Line, on average no significant differences were found in muscle activity between the two workstations for both patients and healthy subjects. Individually in 5 healthy subjects (25%) and in 6 patients (31%) muscle activity was lower when working at the Up-Line. CONCLUSIONS Although some subjects subjectively prefer the Up-Line in sitting comfort, on average the Up-Line did not decrease the muscle activity, both in healthy subjects as in patients with WAD.