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Blocking antibody directed against donor responding cells has been found to develop in HL-A-mixed lymphocyte culture-identical donor-recipient combinations after renal transplantation in which splenectomy was not performed. Cytotoxic antibody associated with rejection episodes and detected only by the discriminatory mixed lymphocyte culture developed in other HL-A-mixed lymphocyte culture-identical combinations as well. It disappeared as blocking antibody appeared and the post-transplant course became uneventful. In addition, both cytotoxic and blocking activity were shown to develop and coexist in a patient who received two successive renal transplants: cytotoxic against donor 1 (kidney rejected), and blocking against donor 2 (kidney accepted). These findings are taken to be strong evidence in favor of qualitatively demonstrable separate antibody molecules dealing with two separate functions, i.e., cytotoxicity versus enhancement or immunoregulation.
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
January 1973,
Surgical forum,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
April 1973,
Cellular immunology,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
December 1971,
Lancet (London, England),
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
January 1973,
Surgical forum,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
November 1972,
Transplantation,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
May 1973,
Lancet (London, England),
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
June 1972,
Transplantation proceedings,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
December 1971,
British medical journal,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
January 1973,
Review of surgery,
J Miller, and
J Lifton, and
F Rood, and
B G Hattler
April 1974,
Transplantation,
