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A pathomorphological investigation of 115 lethal cases of various forms of meningococcal infection was carried out. Meningococcemia, its instantaneous forms in particular, are characterized by acute decompensation of the lymphoid system and generalized microangiopathy with the thrombohaemorrhagic syndrome. Haemorrhagic necrosis of the adrenals and damage of the hypophysis represented manifestations of the acute decompensation of the hormonal regulation. Inflammatory changes in meningococcemia were observed not in all the cases (they were absent in 1/4 of the deceased). In meningitis (meningoencephalitis) without sepsis no generalized angiopathy was noted, immunomorphological changes were of a proliferative character. Previous sensibilization of the macroorganism was an important prerequisite for the development of meningococcal infection.
P S Gurevich, and
N P Popov, and
E P Gurevich
September 2005,
Nature reviews. Immunology,
P S Gurevich, and
N P Popov, and
E P Gurevich
May 1943,
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P S Gurevich, and
N P Popov, and
E P Gurevich
January 1970,
Ceskoslovenska dermatologie,
P S Gurevich, and
N P Popov, and
E P Gurevich
May 1979,
Sovetskaia meditsina,
P S Gurevich, and
N P Popov, and
E P Gurevich
November 1990,
Biulleten' eksperimental'noi biologii i meditsiny,
P S Gurevich, and
N P Popov, and
E P Gurevich
January 1993,
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P S Gurevich, and
N P Popov, and
E P Gurevich
June 1989,
Zhurnal mikrobiologii, epidemiologii i immunobiologii,
P S Gurevich, and
N P Popov, and
E P Gurevich
January 1984,
Voprosy virusologii,
P S Gurevich, and
N P Popov, and
E P Gurevich
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Rheumatologie,
P S Gurevich, and
N P Popov, and
E P Gurevich
June 1975,
Die Medizinische Welt,
