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Effects of isoflurane on the auditory brainstem responses and middle latency responses of rats. 2003

Rosamaria Santarelli, and Edoardo Arslan, and Luigi Carraro, and Guido Conti, and Massimo Capello, and Gilles Plourde
Department of Medical and Surgical Specialities, Service of Audiology and Phoniatrics, University of Padua, Italy. rosamaria.santarelli@unipd.it

OBJECTIVE To evaluate the effects of a volatile anesthetic, isoflurane, on auditory brainstem responses (ABRs) and middle latency responses (MLRs) recorded in rats. METHODS ABRs and MLRs evoked by click stimuli were simultaneously recorded in eight rats in the awake condition and during anesthesia with isoflurane at clinically relevant concentrations. RESULTS Vertex-recorded ABRs showed a significant increase in the latency of waves I-IV during anesthesia and the latency changes appeared to be significantly related to the isoflurane concentration. The I-IV interval also appeared to be significantly increased in comparison to the awake condition, while minor changes in ABR amplitudes were induced by isoflurane. MLRs, which were recorded by means of epidural electrodes implanted over the auditory cortex, appeared to be attenuated in amplitude and increased in latency during anesthesia. Only latency changes appeared to be significantly related to the isoflurane concentration. Moreover, "bursts" of high amplitude MLRs were observed during anesthesia at each concentration. CONCLUSIONS The present findings indicate that both ABR and MLR latencies are increased by isoflurane in a concentration-dependent manner, whilst the anesthetic-induced attenuation in amplitude does not appear to be related to the isoflurane concentration.

UI MeSH Term Description Entries
D007530 Isoflurane A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297 Male Males
D011336 Probability The study of chance processes or the relative frequency characterizing a chance process. Probabilities
D011930 Reaction Time The time from the onset of a stimulus until a response is observed. Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D004056 Differential Threshold The smallest difference which can be discriminated between two stimuli or one which is barely above the threshold. Difference Limen,Just-Noticeable Difference,Weber-Fechner Law,Difference Limens,Difference, Just-Noticeable,Differences, Just-Noticeable,Differential Thresholds,Just Noticeable Difference,Just-Noticeable Differences,Law, Weber-Fechner,Limen, Difference,Limens, Difference,Threshold, Differential,Thresholds, Differential,Weber Fechner Law
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001306 Auditory Pathways NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX. Auditory Pathway,Pathway, Auditory,Pathways, Auditory
D001309 Auditory Threshold The audibility limit of discriminating sound intensity and pitch. Auditory Thresholds,Threshold, Auditory,Thresholds, Auditory
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity

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