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To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.
M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
December 1999,
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M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
December 1972,
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M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
August 2010,
Nature methods,
M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
January 1967,
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M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
July 1964,
Experientia,
M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
August 2023,
Nature ecology & evolution,
M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
October 1965,
Il Farmaco; edizione scientifica,
M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
July 2014,
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M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
January 1991,
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M Krogsgaard Thomsen, and
K Bokvist, and
M Høy, and
K Buschard, and
J J Holst, and
P Lindström, and
J Gromada
January 1978,
Lancet (London, England),
