-transparent.png){kind=logo}
Using the determination of thyroxine (T4) hair content, we studied 16 hypothyroid newborns diagnosed by means of our regional screening program, and five hypothyroid infants, undetected at birth, at diagnosis and after 3 months of substitutive therapy (8-10 microg/kg/day L-thyroxine in newborns; 15 microg/kg/day in infants), and 13 hyperthyroid adults. Hair T4 content was similar at diagnosis in hypothyroid newborns (2.6 +/- 2.3 pg/mg hair) and in infants undetected at birth (2.4 +/- 1.7 microg/mg hair), but very high only in the latter after therapy (23.2 +/- 3.9 microg/mg hair). Untreated hyperthyroid adults surprisingly evidenced lower hair T4 (0.4 +/- 0.2 microg/mg hair) than controls (1.5 +/- 0.3 microg/mg hair). We suggest these findings are due to differential tissue storage of thyroid hormone, related to the different blood T4 concentration. Therefore, T4 hair assay could be a non-invasive method to further assess thyroid status.
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
May 1987,
The Journal of clinical endocrinology and metabolism,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
July 1989,
The New England journal of medicine,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
October 1995,
Clinical pediatrics,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
December 1971,
Journal of medical genetics,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
February 2002,
Archives of disease in childhood,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
May 2003,
Pediatrics,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
November 2005,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
December 1988,
Journal of the Royal Society of Medicine,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
January 1985,
Acta paediatrica Hungarica,
G Zamboni, and
M Camilot, and
G Francia, and
S Lauriola, and
I Arslanoglu, and
P Isguven, and
L Tatò
January 1989,
Journal of medical genetics,
