Biomaterial Database

Lead content of tissues of baby rats born of, and nourished by lead-poisoned mothers. 1976

N P Singh, and I S Thind, and L F Vitale, and M Pawlow

Three groups of Wistar rats (5 males and 5 females in each group) were given zero, 100 mg., and 200 mg. Pb(NO3) 2 per kilogram of body weight per day for 45 days and were mated. The lead feeding was continued throughout the duration of experiments. The blood and urinary lead, blood aminolevulinic acid dehydratase activity, and free erythrocyte protoporphyrin and urinary aminolevulinic acid were measured on these rats at the beginning of the study, at the time of mating, and prior to delivery. The tissues, incuding kidney, liver, heart, and brain of the newborn progeny were analyzed for lead content. The blood lead and aminolevulinic acid dehydratase were also measured (pooled blood). These tissues contained very high amounts of lead when the newborns were killed within half an hour after their birth, a very significant reduction being found after one day with further reduction after 7 days. Kidney and heart contained the highest amount of lead, the levels being dose-related. Three weeks after birth the lead content of tissues rose significantly but blood concentrations remained almost identical to the levels obtained 1 day after birth. There was no evidence of lead accumulation in the brain of the babies...

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D007854	Lead	A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D007855	Lead Poisoning	Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	Poisoning, Lead,Lead Poisonings,Poisonings, Lead
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008431	Maternal-Fetal Exchange	Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.	Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D011248	Pregnancy Complications	Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.	Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011524	Protoporphyrins	Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.