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OBJECTIVE To assess the retinal function in patients with von Hippel-Lindau disease (VHL). METHODS Studies were undertaken in 12 patients (17 eyes) with detected VHL gene mutation and 12 normal healthy controls (17 eyes). METHODS Pattern ERG (PERG), standard flash electroretinogram (ERG) recordings were performed in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards. RESULTS In VHL patients, electrophysiological statistically significant changes were found. In PERG examination, increased latency of P50 was found in the total VHL group (p < 0.02) and in the VHL subgroup with retinal angiomas (p < 0.04). In ERG examination, photopic b-wave latency was increased in the total VHL group (p < 0.03) and also in the VHL subgroup without retinal angiomas (p < 0.05). In OPs, latency increase of OP2, OP3 waves and reduced amplitude of OP3 wave in the total VHL group (OP2 latency, p < 0.05; OP3 latency, p < 0.01; OP3 amplitude, p < 0.03) and in the VHL subgroup with retinal angiomas (OP2 latency, p < 0.02; OP3 latency, p < .008; OP3 amplitude, p < 0.02) were obtained. CONCLUSIONS It can be hypothesized that dysfunction of the inner retinal layer is present in individuals with VHL disease even in patients without retinal angiomas.
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
January 1997,
Bulletin de la Societe belge d'ophtalmologie,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
November 2000,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
January 2014,
The Pan African medical journal,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
January 2017,
Journal francais d'ophtalmologie,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
September 1995,
Archives of ophthalmology (Chicago, Ill. : 1960),
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
April 2005,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
May 2003,
Clinical & experimental optometry,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
January 2006,
Seminars in ophthalmology,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
April 2019,
Medicina clinica,
Wojciech Lubiński, and
Karol Krzystolik, and
Cezary Cybulski, and
Zbigniew Szych, and
Krzysztof Penkala, and
Olgierd Palacz, and
Jan Lubiński
January 1986,
Bulletin de la Societe belge d'ophtalmologie,
