-transparent.png){kind=logo}
A single injection of DMNA induces in hepatocytes different lesions which are revealed by the mitoses following a partial hepatectomy. The inhibition of mitotic activity, the appearance of micronuclei and the development of hyperplastic nodules were investigated. The results show that the delay between the DMNA treatment and the induction of mitotic activity influences differently the evolution of these changes. The lesions reponsible for the inhibition of mitotic activity and the production of micronuclei are produced when DMNA is given before hepatectomy. They remain unchanged for a long period and are still present five weeks after the injection of the carcinogen. They have disappeared after 10 weeks. On the contrary, the lesions leading to the formation of hyperplastic nodules are at their greatest when DMNA is given at the time of the DNA synthesis following hepatectomy. The data of the present work are compared with previous results obtained by combining X irradiation and hepatectomy.
H Barbason, and
A Fridman-Manduzio, and
E H Betz
January 1981,
Oncology,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
December 1971,
The Biochemical journal,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
April 1998,
Archives of oral biology,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
May 1984,
Journal of the National Cancer Institute,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
May 1974,
Experientia,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
March 2003,
Journal of musculoskeletal & neuronal interactions,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
May 1983,
Toxicology and applied pharmacology,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
August 1979,
Cancer research,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
September 1974,
Cell and tissue kinetics,
H Barbason, and
A Fridman-Manduzio, and
E H Betz
July 1973,
British journal of cancer,
