Biomaterial Database

Complexation of butylbenzenes with 2-hydroxypropyl-cyclodextrins in aqueous solution. 2003

Yoshihiro Saito, and Kaname Hashizaki, and Hiroyuki Taguchi, and Naotake Ogawa

College of Pharmacy, Nihon University, Chiba, Japan. ysaito@pha.nihon-u.ac.jp

The stability constants for the inclusion of butylbenzenes (BBs) with 2-hydroxypropyl-cyclodextrins (2HP-CDs) in aqueous solution have been determined using the static head-space method. The 1:1 stability constants were obtained by this method. For the complexation of BBs by 2HP-alpha-CD, the order of stability constants was n-BB > isoBB > tert-BB. In contrast, the order for complexation of BBs by 2HP-beta-CD was the opposite: tert-BB > isoBB > n-BB. The order of the stability constants by 2HP-gamma-CD was similar to that of 2HP-beta-CD, but the values of the stability constants were not significantly different in the BB types. In addition, the binding effects are discussed in relation to the different alkyl groups of BBs.

UI	MeSH Term	Description	Entries
D008956	Models, Chemical	Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.	Chemical Models,Chemical Model,Model, Chemical
D003505	Cyclodextrins	A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.	Cycloamylose,Cyclodextrin,Cyclodextrin Derivatives,Cyclomaltooligosaccharides,Derivatives, Cyclodextrin
D004785	Environmental Pollutants	Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.	Environmental Pollutant,Pollutant,Pollutants,Pollutants, Environmental,Pollutant, Environmental
D000073738	2-Hydroxypropyl-beta-cyclodextrin	Derivative of beta-cyclodextrin that is used as an excipient for steroid drugs and as a lipid chelator.	2 Hydroxypropyl-beta-cyclodextrin,HP-beta-CD,HPbetaCD,Hydroxypropyl Betadex,Hydroxypropyl-beta-cyclodextrin,beta-Hydroxypropylcyclodextrin,2 Hydroxypropyl beta cyclodextrin,Betadex, Hydroxypropyl,Hydroxypropyl beta cyclodextrin,beta Hydroxypropylcyclodextrin
D001555	Benzene Derivatives	Organic compounds derived from BENZENE.	Derivatives, Benzene
D014835	Volatilization	A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.	Vaporization,Volatility
D047391	alpha-Cyclodextrins	Cyclic GLUCANS consisting of six (6) glucopyranose units linked by 1,4-glycosidic bonds.	alpha Cyclodextrins
D047392	beta-Cyclodextrins	Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.	beta Cyclodextrins
D047408	gamma-Cyclodextrins	Cyclic GLUCANS consisting of eight (8) glucopyranose units linked by 1,4-glycosidic bonds.	gamma Cyclodextrins