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Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium). 2003

Marie Van der Wielen, and Pierre Van Damme, and Koen Van Herck, and Susanna Schlegel-Haueter, and Claire-Anne Siegrist
Department of Epidemiology and Social Medicine, WHO Collaborating Centre for Prevention and Control of Viral Hepatitis, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.

To determine age-dependent pertussis immune response in the Flemish population, antibody levels to pertactin (PRN), pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in serum samples from 1622 healthy 1-100-year-old subjects. For anti-PRN and anti-PT antibodies, peaks in GMTs were seen in infancy and again in the 10-15-year age group. After age of 20 years, anti-PRN GMT declined rapidly over a decade, followed by a slower decline. Anti-FHA GMT tended to rather increase progressively with age. These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000907 Antibodies, Bacterial Immunoglobulins produced in a response to BACTERIAL ANTIGENS. Bacterial Antibodies

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