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OBJECTIVE To investigate the effect of the contrast medium (CM) iopromide on renal microcirculation and oxygen tension in non-diabetic control and streptozotocin-diabetic Wistar Furth rats. METHODS Oxygen tension was measured with Clark-type microelectrodes and blood flow with laser-Doppler flow probes. In order to differentiate between an acutely increased blood glucose concentration and a long-term diabetic state, some of the non-diabetic control rats were intravenously infused with glucose. RESULTS CM decreased the medullary oxygen tension in control (non-diabetic normoglycemic) rats ( approximately 35%) but not in diabetic rats. Medullary blood flow in control rats increased after CM administration and remained elevated, while it was unchanged in the diabetic rats. In response to CM, glucose-infused control rats responded similarly to control animals in medullary oxygen tension, but similarly to diabetic rats in medullary blood flow. Contrary to in control rats, medullary oxygen tension was unchanged in diabetic animals after CM administration. CONCLUSIONS Streptozotocin-diabetic rats have an altered response to intravenous injection of the CM iopromide compared to non-diabetic rats. The unaltered medullary oxygen tension, seen in the diabetic group after injection of CM, suggests that non-hemodynamic mechanisms are responsible for the increased frequency of renal failure commonly seen among diabetic patients.
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
January 1992,
Advances in experimental medicine and biology,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
January 1977,
Annales chirurgiae et gynaecologiae. Supplementum,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
May 1993,
Acta radiologica (Stockholm, Sweden : 1987),
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
January 1982,
Clinical and experimental dermatology,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
May 1977,
Experientia,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
June 1971,
The American journal of physiology,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
November 2009,
Investigative ophthalmology & visual science,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
September 1984,
Brain : a journal of neurology,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
November 2016,
The Journal of physiology,
F Palm, and
P-O Carlsson, and
P Hansell, and
O Hellberg, and
A Nygren, and
P Liss
February 1977,
Radiology,
