[Iron and transferrin metabolism]. 1976

C E Marcovich, and J Marcovich, and D Kersvenovich

The study comprised 36 patients who were divided into two groups. In the first one, there were acute or chronic infectious diseases and the second was a control group. In all of them, the following laboratory counts were done: hemoglobin, hematocrit, leukocyte; also, measurement of protein electrophoresis, of serum iron and of total fixation capacity of iron (transferrin). The procedure was that of a blind study, so that the laboratories responsible for the measurements were not given any clinical information on the different patients. Hypochromic anemia of different degrees of severeness was reported in all infected patients and was attributted to nutritional and infectious factors. In spite of decreased levels of hemoglobin and iron, it was shown that transferrin did not rise, but otherwise, dropped in these patients; therefore, the capacity to convey and fix iron is decreased. This would be a fact resulting in a greater susceptibility, to suffer infections, as has been confirmed in previous studies. A close relationship was found at pediatric level among hypochromic anemia, drop in transferrin levels, poor nutrition and increase of infectious diseases.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007228 Infant Nutrition Disorders Disorders caused by nutritional imbalance, either overnutrition or undernutrition, occurring in infants ages 1 month to 24 months. Infant Malnutrition,Malnutrition, Infant,Nutrition Disorders, Infant,Infant Overnutrition,Infantile Malnutrition,Malnutrition in Infant,Infant Nutrition Disorder,Malnutrition in Infants,Malnutrition, Infantile,Nutrition Disorder, Infant,Overnutrition, Infant
D007239 Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases. Infection,Infection and Infestation,Infections and Infestations,Infestation and Infection,Infestations and Infections
D007501 Iron A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Iron-56,Iron 56
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000747 Anemia, Hypochromic Anemia characterized by a decrease in the ratio of the weight of hemoglobin to the volume of the erythrocyte, i.e., the mean corpuscular hemoglobin concentration is less than normal. The individual cells contain less hemoglobin than they could have under optimal conditions. Hypochromic anemia may be caused by iron deficiency from a low iron intake, diminished iron absorption, or excessive iron loss. It can also be caused by infections or other diseases, therapeutic drugs, lead poisoning, and other conditions. (Stedman, 25th ed; from Miale, Laboratory Medicine: Hematology, 6th ed, p393) Chlorosis,Anemias, Hypochromic,Chloroses,Hypochromic Anemia,Hypochromic Anemias

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