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The continuous administration of nitrous oxide, in subjects who remain conscious, caused only a relatively small increase in the threshold of appreciation of pain, induced experimentally by tibial pressure and a hot wire applied to the thenar eminence. The threshold reached a maximum at 10 min. A concentration of 50% nitrous oxide caused only a marginally greater effect than 33%. In some subjects pain thresholds returned to control values during administration of the gas. In contrast, when a concentration of 50% nitrous oxide was approached in step changes of 7-10% over a period of 45 min, the effect on the pain threshold was more than doubled. It was concluded that, with respect to analgesia, adaptation of the nervous system to a constant concentration of nitrous oxide can occur in some subjects.
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
September 1998,
Anesthesiology,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
May 1981,
Annals of emergency medicine,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
May 1910,
British medical journal,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
January 2001,
British journal of anaesthesia,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
March 1933,
Canadian Medical Association journal,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
November 1868,
The American journal of dental science,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
September 1977,
Chest,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
February 1989,
Anaesthesia and intensive care,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
August 1969,
British medical journal,
J G Whitwam, and
M Morgan, and
G M Hall, and
A Petrie
January 1984,
Anesthesia progress,
