Biomaterial Database

Mismatch negativity: clinical research and possible applications. 2003

Risto Näätänen

Cognitive Brain Research Unit, Department of Psychology, University of Helsinki, P.O. Box 9 (Siltavuorenpenger 20 C), 00014, Helsinki, Finland. risto.naatanen@helsinki.fi

This article provides a selective review on the perspectives of the clinical research and application of the mismatch negativity (MMN), a component of the auditory event-related potential generated by the brain's automatic response to any discriminable change in auditory stimulation. The MMN (and its magnetic equivalent MMNm) currently provide the only objective measure of auditory discrimination and sensory memory. It can be registered in the absence of attention and with no task requirements, which makes it particularly suitable for studying different clinical populations and infants.

UI	MeSH Term	Description	Entries
D007839	Functional Laterality	Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.	Ambidexterity,Behavioral Laterality,Handedness,Laterality of Motor Control,Mirror Writing,Laterality, Behavioral,Laterality, Functional,Mirror Writings,Motor Control Laterality,Writing, Mirror,Writings, Mirror
D009462	Neurology	A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.
D011570	Psychiatry	The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders.
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D003265	Contingent Negative Variation	A negative shift of the cortical electrical potentials that increases over time. It is associated with an anticipated response to an expected stimulus and is an electrical event indicative of a state of readiness or expectancy.	Bereitschaftspotential,Readiness Potential,Bereitschaftspotentials,Contingent Negative Variations,Potential, Readiness,Potentials, Readiness,Readiness Potentials,Variation, Contingent Negative,Variations, Contingent Negative
D004192	Discrimination, Psychological	Differential response to different stimuli.	Discrimination, Psychology,Psychological Discrimination
D004410	Dyslexia	A cognitive disorder characterized by an impaired ability to comprehend written and printed words or phrases despite intact vision. This condition may be developmental or acquired. Developmental dyslexia is marked by reading achievement that falls substantially below that expected given the individual's chronological age, measured intelligence, and age-appropriate education. The disturbance in reading significantly interferes with academic achievement or with activities of daily living that require reading skills. (From DSM-IV)	Alexia,Dyslexia, Developmental,Reading Disability, Developmental,Reading Disorder,Reading Disorder, Developmental,Developmental Reading Disorder,Word Blindness,Alexias,Blindness, Word,Blindnesses, Word,Developmental Dyslexia,Developmental Dyslexias,Developmental Reading Disabilities,Developmental Reading Disability,Developmental Reading Disorders,Disabilities, Developmental Reading,Disability, Developmental Reading,Disorder, Developmental Reading,Disorder, Reading,Disorders, Developmental Reading,Disorders, Reading,Dyslexias,Dyslexias, Developmental,Reading Disabilities, Developmental,Reading Disorders,Reading Disorders, Developmental,Word Blindnesses
D004569	Electroencephalography	Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.	EEG,Electroencephalogram,Electroencephalograms
D005072	Evoked Potentials, Auditory	The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.	Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked