Biomaterial Database

Skeletal muscle cellularity in mice selected for large body size and in controls. 1976

E D Aberle, and D P Doolittle

Body composition and skeletal muscle weights, fiber diameters, fiber numbers, and RNA and DNA concentrations were studied in mice selected for large body size (GLW) compared to an unselected control (C) line. At 60 days of age, body weight of GLW mice was 70 to 75% greater than C mice, but % body water, fat or dry fat-free residue did not differ between the lines. In both GLW and C mice, greater muscle weight in males compared to females was due to larger diameter fibers and not to significant differences in fiber number between sexes, although in most cases, males had slightly higher mean fiber number. Fiber diameters were similar in the two lines and the greater muscle weights of GLW mice were due to more fibers than in the muscles of C mice. RNA and DNA concentrations were slightly, but not significantly, higher in GLW skeletal muscles.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D001823	Body Composition	The relative amounts of various components in the body, such as percentage of body fat.	Body Compositions,Composition, Body,Compositions, Body
D001824	Body Constitution	The physical characteristics of the body, including the mode of performance of functions, the activity of metabolic processes, the manner and degree of reactions to stimuli, and power of resistance to the attack of pathogenic organisms.	Body Constitutions,Constitution, Body,Constitutions, Body
D001834	Body Water	Fluids composed mainly of water found within the body.	Water, Body
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004247	DNA	A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).	DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005260	Female		Females