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Aspirin induces hepatoma-derived cell apoptosis via a hydrogen peroxide-dependent pathway. 2003

Demidmaa Tuvdendorj, and Makoto Oketani, and Ryuji Ikeda, and Kazunori Kohara, and Yasuzi Komorizono, and Kazuaki Ishibashi, and Namid Munkhtuvshin, and Terukatsu Arima
Faculty of Medicine, Second Department of Internal Medicine, Kagoshima University, Sakuragaoka 8 chome 35-1, Kagoshima, Japan

Here we studied whether aspirin (ASA) has any influence on viability of human hepatoma-derived SKHep-1 cells and whether hydrogen peroxide (H(2)O(2)) has any relation with this effect. ASA inhibited SKHep-1 cell proliferation dose- and time-dependently. Intracellular H(2)O(2) increased as early as 15 min after ASA supplementation. Cellular apoptosis correlated with an increase in intracellular H(2)O(2) level. Moreover, in the presence of a catalase inhibitor-aminotriazol, ASA showed more apoptotic effect on SKHep-1 cells with increasing intracellular H(2)O(2) level. In conclusion, the present results shows that ASA induced SKHep-1 cell apoptosis has a relation with an early increase in intracellular H(2)O(2) level and catalase inhibitor synergizes to induce this process.

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