Lipid profile, insulin secretion, and insulin sensitivity in psoriasis. 2003

Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
Medical Research Unit in Clinical Epidemiology, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.

BACKGROUND Psoriasis has been associated with an abnormal plasma lipid metabolism and diabetes mellitus possibly related to alterations in insulin secretion and sensitivity. OBJECTIVE We sought to identify lipid profile, insulin secretion, and insulin sensitivity in patients with psoriasis and healthy control patients. METHODS A cross-sectional study was performed in 44 nonobese adults, 22 with psoriasis and 22 without. The psoriasis activity was evaluated by the psoriasis area and severity index. Insulin secretion was estimated using the homeostasis model analysis beta-cell function index. Insulin sensitivity was assessed with the insulin tolerance test. RESULTS High-density lipoprotein cholesterol was significantly decreased in patients with psoriasis (P =.02). There were no significant differences in insulin secretion or sensitivity in patients with psoriasis compared with control patients. CONCLUSIONS Patients with psoriasis had significantly decreased high-density lipoprotein cholesterol concentrations. There were no differences in insulin secretion or sensitivity compared with control patients.

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007333 Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. Insulin Sensitivity,Resistance, Insulin,Sensitivity, Insulin
D008076 Cholesterol, HDL Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol. High Density Lipoprotein Cholesterol,Cholesterol, HDL2,Cholesterol, HDL3,HDL Cholesterol,HDL(2) Cholesterol,HDL(3) Cholesterol,HDL2 Cholesterol,HDL3 Cholesterol,alpha-Lipoprotein Cholesterol,Cholesterol, alpha-Lipoprotein,alpha Lipoprotein Cholesterol
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011565 Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D003430 Cross-Sectional Studies Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time. Disease Frequency Surveys,Prevalence Studies,Analysis, Cross-Sectional,Cross Sectional Analysis,Cross-Sectional Survey,Surveys, Disease Frequency,Analyses, Cross Sectional,Analyses, Cross-Sectional,Analysis, Cross Sectional,Cross Sectional Analyses,Cross Sectional Studies,Cross Sectional Survey,Cross-Sectional Analyses,Cross-Sectional Analysis,Cross-Sectional Study,Cross-Sectional Surveys,Disease Frequency Survey,Prevalence Study,Studies, Cross-Sectional,Studies, Prevalence,Study, Cross-Sectional,Study, Prevalence,Survey, Cross-Sectional,Survey, Disease Frequency,Surveys, Cross-Sectional
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000078790 Insulin Secretion Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels. Secretion, Insulin
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
March 2008, Acta physiologica Hungarica,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
July 1985, Vestnik dermatologii i venerologii,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
December 1992, Bollettino della Societa italiana di biologia sperimentale,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
July 2013, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
January 2004, American journal of physiology. Heart and circulatory physiology,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
January 2005, Journal of diabetes and its complications,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
November 2008, Diabetes & metabolism,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
January 1977, Archives for dermatological research = Archiv fur dermatologische Forschung,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
January 2006, European journal of endocrinology,
Claudia Reynoso-von Drateln, and Esperanza Martínez-Abundis, and Blanca Rebeca Balcázar-Muñoz, and Rafael Bustos-Saldaña, and Manuel González-Ortiz
January 1990, Clinical physiology and biochemistry,
Copied contents to your clipboard!