Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. 2003

Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshidakonoe-cho, 606-8501 Kyoto, Japan.

Dbl-family guanine nucleotide exchange factors (Dbl-GEFs) act as activators of Rho-like small G proteins such as Rac1, Cdc42 and RhoA. Recently, some GEFs have been suggested to play important roles in the development of the nervous system. Here, we report a comprehensive expression profile analysis of 20 Dbl-GEFs that have yet to be well investigated. Northern analyses of murine mRNAs from brains of E13, E17, P7 and adult mice revealed expression of 18 out of 20 GEFs in some or all stages. In addition, we found that three human GEFs were highly expressed in the brain. Examination of the spatial expression patterns of five GEFs in embryos or neonatal brain by in situ hybridization revealed distinct patterns for each GEF. Our study reveals the dynamic and coordinated expression profiles of the Dbl-GEFs and provides a basic framework for understanding the function of GEFs in neural development.

UI MeSH Term Description Entries
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D005810 Multigene Family A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed) Gene Clusters,Genes, Reiterated,Cluster, Gene,Clusters, Gene,Families, Multigene,Family, Multigene,Gene Cluster,Gene, Reiterated,Multigene Families,Reiterated Gene,Reiterated Genes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016415 Sequence Alignment The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms. Sequence Homology Determination,Determination, Sequence Homology,Alignment, Sequence,Alignments, Sequence,Determinations, Sequence Homology,Sequence Alignments,Sequence Homology Determinations
D017403 In Situ Hybridization A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes. Hybridization in Situ,Hybridization, In Situ,Hybridizations, In Situ,In Situ Hybridizations
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018507 Gene Expression Regulation, Developmental Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. Developmental Gene Expression Regulation,Embryologic Gene Expression Regulation,Gene Expression Regulation, Embryologic,Regulation of Gene Expression, Developmental,Regulation of Gene Expression, Embryologic,Regulation, Gene Expression, Developmental,Regulation, Gene Expression, Embryologic

Related Publications

Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
December 2001, Trends in biochemical sciences,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
September 2015, Journal of chemical information and modeling,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
August 1996, The Journal of biological chemistry,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
January 1995, Methods in enzymology,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
August 2010, The Journal of cell biology,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
October 1999, FEBS letters,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
May 2013, The Journal of biological chemistry,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
February 1997, The Journal of biological chemistry,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
May 2012, Molecular medicine reports,
Masato Yoshizawa, and Masaki Sone, and Naoki Matsuo, and Takahiro Nagase, and Osamu Ohara, and Yo-ichi Nabeshima, and Mikio Hoshino
May 2010, Journal of neuroendocrinology,
Copied contents to your clipboard!