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We studied the influence of various methods for correction of age-related changes (administration of N-acetyl-L-cysteine, vitamins C and E, melatonin, and carnosine and swimming training) on the realization of estrogens effects in ovariectomized rats. The proliferation index in the endometrium decreased in 12-14-month-old control animals. The weight of the uterus, percentage of "comets", and average length of their tail in estradiol-treated rats far surpassed the corresponding parameters in control animals. Administration of melatonin and N-acetyl-L-cysteine and swimming training corrected these genotoxic abnormalities. Our results indicate that aging induces incomplete variant of the phenomenon for switching of estrogen's effects (increase in the severity of genotoxic damage without facilitation of the hormonal effect). These methods for correction of age-related changes have not only common, but also distinguishing characteristics compared to correction of changed induced by drinking of ethanol in various concentrations, whole body gamma-irradiation, and exposure to tobacco smoke.
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
June 1971,
Toxicology and applied pharmacology,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
January 1969,
Fertility and sterility,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
January 1981,
Journal of toxicology and environmental health,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
July 1996,
Progress in neuro-psychopharmacology & biological psychiatry,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
October 1997,
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
May 1983,
Proceedings of the National Academy of Sciences of the United States of America,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
January 1982,
Indian journal of physiology and pharmacology,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
August 1983,
Endocrinology,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
June 1959,
Archives des maladies de l'appareil digestif et des maladies de la nutrition,
L M Bershtein, and
E V Tsyrlina, and
T E Poroshina, and
Yu M Rozanov, and
V B Gamayunova, and
D A Vasil'ev, and
I G Kovalenko
October 1959,
Gastroenterology,
