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Bleomycetin, an antitumor antibiotic, was subjected to chemical modification by the C-end fragment i.e. the residue of 3-[(4-aminobutyl)amino]propylamine (spermidine++) with acylation, carbamoylation and reducing alkylation, which yielded its new semisynthetic derivatives. The use of physicochemical methods showed that the chemical modification involved the primary and secondary amino groups++ of spermidine++ and gave rise to N,N'-diacyl, N,N'-dicarbamoyl and N,N'-dialkyl bleomycetins. The biological properties of the derivatives, i.e. their cytotoxic activity, acute and pulmonary toxicities were studied. The transformation of bleomycetin by the C-end fragment lowered the antibiotic toxicity and was believed to be a promising approach to modifying its molecule.
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
December 1982,
Antibiotiki,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
March 1982,
Antibiotiki,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
January 1988,
Voprosy onkologii,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
January 1981,
Vestnik Akademii meditsinskikh nauk SSSR,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
January 1997,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
December 1980,
Antibiotiki,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
September 1966,
Antibiotiki,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
December 1988,
The Journal of antibiotics,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
May 1982,
Antibiotiki,
G P Andronnikova, and
N N Lomakina, and
T M Anisimova, and
S V Usol'tseva, and
V A Zenkova, and
G M Anoshina, and
O P Bychkova, and
L E Gol'dberg, and
E S Stepanova
August 1984,
Antibiotiki,
