BIOMAT Database Logo BIOMAT Database Logo

Unimodal circadian rhythm in the suprachiasmatic nucleus of behaviorally splitting mice. 2003

Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Division of Biomodeling, Graduate school of Bioagricultural Sciences, Nagoya University, Japan.

CS mice exhibit rhythm splitting in constant darkness (DD). To examine the anatomical and physiological bases of this phenomenon, mouse Period1 (mPer1)-driven green fluorescent protein (GFP) mice with rhythm splitting were produced by crossing CS and mPer1::GFP mice. GFP expression in the suprachiasmatic nucleus (SCN) slices showed a clear unimodal rhythm with the highest level at circadian time (CT) 8 or CT12 in splitting and non-splitting GFP mice under DD and no essential differences in the pattern of GFP expression were found between these mice. Moreover, there were no significant differences in the degree of symmetry in the paired rostral, central and caudal SCN between splitting and non-splitting mice. These results indicate that behavioral rhythm splitting in CS mice does not reflect the pattern of clock gene expression in the SCN.

UI MeSH Term Description Entries
D008164 Luminescent Proteins Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors. Bioluminescent Protein,Bioluminescent Proteins,Luminescent Protein,Photoprotein,Photoproteins,Protein, Bioluminescent,Protein, Luminescent,Proteins, Bioluminescent,Proteins, Luminescent
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009687 Nuclear Proteins Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. Nucleolar Protein,Nucleolar Proteins,Nuclear Protein,Protein, Nuclear,Protein, Nucleolar,Proteins, Nuclear,Proteins, Nucleolar
D011401 Promoter Regions, Genetic DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes. rRNA Promoter,Early Promoters, Genetic,Late Promoters, Genetic,Middle Promoters, Genetic,Promoter Regions,Promoter, Genetic,Promotor Regions,Promotor, Genetic,Pseudopromoter, Genetic,Early Promoter, Genetic,Genetic Late Promoter,Genetic Middle Promoters,Genetic Promoter,Genetic Promoter Region,Genetic Promoter Regions,Genetic Promoters,Genetic Promotor,Genetic Promotors,Genetic Pseudopromoter,Genetic Pseudopromoters,Late Promoter, Genetic,Middle Promoter, Genetic,Promoter Region,Promoter Region, Genetic,Promoter, Genetic Early,Promoter, rRNA,Promoters, Genetic,Promoters, Genetic Middle,Promoters, rRNA,Promotor Region,Promotors, Genetic,Pseudopromoters, Genetic,Region, Genetic Promoter,Region, Promoter,Region, Promotor,Regions, Genetic Promoter,Regions, Promoter,Regions, Promotor,rRNA Promoters
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003433 Crosses, Genetic Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species. Cross, Genetic,Genetic Cross,Genetic Crosses
D003624 Darkness The absence of light. Darknesses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013493 Suprachiasmatic Nucleus An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM. Hypothalamic Suprachiasmatic Nuclei,Hypothalamic Suprachiasmatic Nucleus,Suprachiasmatic Nuclei,Suprachiasmatic Nuclei, Hypothalamic,Suprachiasmatic Nucleus, Hypothalamic

Related Publications

Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Circadian rhythm generation in the cultured suprachiasmatic nucleus.
January 1995, Brain research bulletin,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Neurochemical organization of circadian rhythm in the suprachiasmatic nucleus.
August 1994, Neuroscience research,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
The suprachiasmatic nucleus functions beyond circadian rhythm generation.
November 2007, Neuroscience,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
GABAergic mechanisms in the suprachiasmatic nucleus that influence circadian rhythm.
April 2021, Journal of neurochemistry,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Circadian rhythm. Dysrhythmia in the suprachiasmatic nucleus inhibits memory processing.
November 2014, Science (New York, N.Y.),
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus.
July 2004, Journal of neurophysiology,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
May 2002, Nature,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus.
January 2023, Science advances,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Dual origins of the intracellular circadian calcium rhythm in the suprachiasmatic nucleus.
February 2017, Scientific reports,
Tsuyoshi Watanabe, and Takashi Yoshimura, and Douglas G McMahon, and Shizufumi Ebihara
Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus.
July 1988, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!