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Protein-tyrosine phosphorylation and dephosphorylation are directly associated with cellular growth, signal transduction, and neoplastic transformation. Here we report the isolation of a complementary DNA (cDNA) clone encoding a novel protein-tyrosine phosphatase (PTP) from a human T cell PEER cDNA library. The predicted open reading frame encodes a approximately 68-kDa protein composed of 593 amino acids which contains two src-homology region 2's (SH2 domains) at the N terminus; this PTP is designated as SH-PTP3. Northern blot analysis revealed that SH-PTP3 mRNA was expressed throughout many tissues and the transcriptional size was consistent at about 6.0 kb. As with other SH2 domains in src-family kinases, the SH2 domains of SH-PTP3 may play a crucial role in interactions with tyrosine phosphorylated signaling proteins, including itself and protein tyrosine kinases (PTKs), to regulate targets' enzyme activity.
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M Sekiya, and
T Miyachi, and
K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
October 1992,
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M Adachi, and
M Sekiya, and
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Y Hinoda, and
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A Yachi
February 1996,
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M Adachi, and
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A Yachi
December 1994,
Biochemistry,
M Adachi, and
M Sekiya, and
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K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
October 1994,
Molecular and cellular biology,
M Adachi, and
M Sekiya, and
T Miyachi, and
K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
June 1995,
Biochemical and biophysical research communications,
M Adachi, and
M Sekiya, and
T Miyachi, and
K Matsuno, and
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A Yachi
September 2007,
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences,
M Adachi, and
M Sekiya, and
T Miyachi, and
K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
February 1992,
Proceedings of the National Academy of Sciences of the United States of America,
M Adachi, and
M Sekiya, and
T Miyachi, and
K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
May 1998,
The Journal of biological chemistry,
M Adachi, and
M Sekiya, and
T Miyachi, and
K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
March 1993,
Proceedings of the National Academy of Sciences of the United States of America,
M Adachi, and
M Sekiya, and
T Miyachi, and
K Matsuno, and
Y Hinoda, and
K Imai, and
A Yachi
August 1997,
The Journal of experimental medicine,
