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Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine. 2003
Fausto Baldanti, and
Stefania Paolucci, and
Giovanni Maga, and
Nazzarena Labo, and
Ulrich Hübscher, and
Alexander Yu Skoblov, and
Lyubov Victorova, and
Silvio Spadari, and
Lorenzo Minoli, and
Giuseppe Gerna
Servizio di Virologia, IRCCS Policlinico San Matteo, Pavia, Italy.
Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI)-treated patients. However, recombinant Y181C HIV-1 showed reduced stavudine susceptibility with respect to both recombinant wild-type and K103N HIV-1 strains. In addition, recombinant Y181I RT enzyme showed reduced susceptibility to stavudine with respect to both wild-type and K103N RT. A previously unnoticed role of Y181I/C RT changes selected by nevirapine or other NNRTI in determining stavudine resistance is documented.
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