Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. 2003

Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
Department of Nephrology, Institute of Pediatrics, Medical University, PoznaƄ, Poland. zachwiej@mp.pl

BACKGROUND The aim of the present study was to estimate the total antioxidant status (TAS) and main antioxidant enzyme activity in children with nephrotic syndrome (NS). METHODS The study was carried out in a group of 82 children with NS, age 4-16 years (mean 7.4). Of these, 59 with a first episode formed group I, and 23 children in remission (>6 months, with no immunosuppressive treatment) formed group II. TAS was estimated using the two-reagent Randox Total Antioxidant Status test in plasma. RESULTS TAS was significantly reduced in group I compared to controls (0.77+/-0.14 mmol/l vs. 1.18+/-0.42 mmol/l; p<0.001). The TAS level was more reduced in those patients with higher total cholesterol (TChol) and low density lipoproteins cholesterol (LDL-cholesterol). In children from group I the activity of glutathione reductase (GR) was lower than in the controls (8.10+/-2.40 U/g Hb vs. 10.55+/-3.81 U/g Hb, p<0.001) and similarly the activity of glutathione peroxidase (GPX) was lower in group I compared to controls (28.65+/-6.99 U/g Hb vs. 33.84+/-13.11 U/g Hb, p=0.010). There was no significant difference in superoxide dismutase (SOD) activity between the 3 groups. CONCLUSIONS Reduced antioxidant activity may be related to lipid abnormalities in NS.

UI MeSH Term Description Entries
D008074 Lipoproteins Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes. Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D009404 Nephrotic Syndrome A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction. Childhood Idiopathic Nephrotic Syndrome,Frequently Relapsing Nephrotic Syndrome,Multi-Drug Resistant Nephrotic Syndrome,Pediatric Idiopathic Nephrotic Syndrome,Steroid-Dependent Nephrotic Syndrome,Steroid-Resistant Nephrotic Syndrome,Steroid-Sensitive Nephrotic Syndrome,Multi Drug Resistant Nephrotic Syndrome,Nephrotic Syndrome, Steroid-Dependent,Nephrotic Syndrome, Steroid-Resistant,Nephrotic Syndrome, Steroid-Sensitive,Nephrotic Syndromes,Steroid Dependent Nephrotic Syndrome,Steroid Resistant Nephrotic Syndrome,Steroid Sensitive Nephrotic Syndrome,Steroid-Dependent Nephrotic Syndromes,Steroid-Resistant Nephrotic Syndromes,Steroid-Sensitive Nephrotic Syndromes,Syndrome, Nephrotic,Syndrome, Steroid-Sensitive Nephrotic
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001798 Blood Proteins Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins. Blood Protein,Plasma Protein,Plasma Proteins,Serum Protein,Serum Proteins,Protein, Blood,Protein, Plasma,Protein, Serum,Proteins, Blood,Proteins, Plasma,Proteins, Serum
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol
D005979 Glutathione Peroxidase An enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water. Cytosolic Glutathione Peroxidase,Glutathione Lipoperoxidase,Selenoglutathione Peroxidase,Glutathione Peroxidase, Cytosolic,Lipoperoxidase, Glutathione,Peroxidase, Glutathione,Peroxidase, Selenoglutathione
D005980 Glutathione Reductase Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2. Glutathione-Disulfide Reductase,Reductase, Glutathione,Reductase, Glutathione-Disulfide

Related Publications

Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
December 1984, The International journal of pediatric nephrology,
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
February 2011, Pediatric nephrology (Berlin, Germany),
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
January 2015, Clinical laboratory,
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
November 1998, Pediatric nephrology (Berlin, Germany),
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
November 2013, Nephro-urology monthly,
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
October 1991, Thrombosis and haemostasis,
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
January 1963, The Journal of pediatrics,
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
March 1989, Nihon Jinzo Gakkai shi,
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
October 2005, Pediatric nephrology (Berlin, Germany),
Jacek Zachwieja, and Waldemar Bobkowski, and Agnieszka Dobrowolska-Zachwieja, and Marcin Zaniew, and Janusz Maciejewski
November 1993, Kidney international,
Copied contents to your clipboard!