BIOMAT Database Logo BIOMAT Database Logo

Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. 2003

Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei City, Taiwan 110-31.

The antihyperglycemic action of puerarin, purified from the roots of Pueraria lobata, was investigated in streptozotocin-induced diabetic rats (STZ-diabetic rats). Bolus intravenous injection of puerarin decreased the plasma glucose concentrations in a dose-dependent manner in STZ-diabetic rats. Similar treatment with puerarin also decreased the plasma glucose in normal rats, although the effect was not as great as that in STZ-diabetic rats. Puerarin at the effective dose (15.0 mg/kg) significantly attenuated the increase of plasma glucose induced by an intravenous glucose challenge test in normal rats. In the isolated soleus muscle of STZ-diabetic rats, puerarin enhanced the uptake of radioactive glucose in a concentration-dependent manner. Moreover, the mRNA and protein levels of the subtype 4 form of glucose transporter (GLUT4) in soleus muscle were increased after repeated intravenous administration of puerarin in STZ-diabetic rats for 3 days. These results suggest that puerarin can increase the glucose utilization to lower plasma glucose in diabetic rats lacking insulin.

UI MeSH Term Description Entries
D007004 Hypoglycemic Agents Substances which lower blood glucose levels. Antidiabetic,Antidiabetic Agent,Antidiabetic Drug,Antidiabetics,Antihyperglycemic,Antihyperglycemic Agent,Hypoglycemic,Hypoglycemic Agent,Hypoglycemic Drug,Antidiabetic Agents,Antidiabetic Drugs,Antihyperglycemic Agents,Antihyperglycemics,Hypoglycemic Drugs,Hypoglycemic Effect,Hypoglycemic Effects,Hypoglycemics,Agent, Antidiabetic,Agent, Antihyperglycemic,Agent, Hypoglycemic,Agents, Antidiabetic,Agents, Antihyperglycemic,Agents, Hypoglycemic,Drug, Antidiabetic,Drug, Hypoglycemic,Drugs, Antidiabetic,Drugs, Hypoglycemic,Effect, Hypoglycemic,Effects, Hypoglycemic
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007529 Isoflavones 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position. 3-Benzylchroman-4-One,3-Benzylidene-4-Chromanone,Homoisoflavone,Homoisoflavones,Isoflavone,Isoflavone Derivative,3-Benzylchroman-4-Ones,3-Benzylidene-4-Chromanones,Isoflavone Derivatives,3 Benzylchroman 4 One,3 Benzylchroman 4 Ones,3 Benzylidene 4 Chromanone,3 Benzylidene 4 Chromanones,Derivative, Isoflavone,Derivatives, Isoflavone
D009004 Monosaccharide Transport Proteins A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES. Hexose Transport Proteins,Band 4.5 Preactin,Erythrocyte Band 4.5 Protein,Glucose Transport-Inducing Protein,Hexose Transporter,4.5 Preactin, Band,Glucose Transport Inducing Protein,Preactin, Band 4.5,Proteins, Monosaccharide Transport,Transport Proteins, Hexose,Transport Proteins, Monosaccharide,Transport-Inducing Protein, Glucose
D009124 Muscle Proteins The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN. Muscle Protein,Protein, Muscle,Proteins, Muscle
D010946 Plants, Medicinal Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals. Herbs, Medicinal,Medicinal Herbs,Healing Plants,Medicinal Plants,Pharmaceutical Plants,Healing Plant,Herb, Medicinal,Medicinal Herb,Medicinal Plant,Pharmaceutical Plant,Plant, Healing,Plant, Medicinal,Plant, Pharmaceutical,Plants, Healing,Plants, Pharmaceutical
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003921 Diabetes Mellitus, Experimental Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY. Alloxan Diabetes,Streptozocin Diabetes,Streptozotocin Diabetes,Experimental Diabetes Mellitus,Diabete, Streptozocin,Diabetes, Alloxan,Diabetes, Streptozocin,Diabetes, Streptozotocin,Streptozocin Diabete
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response

Related Publications

Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of andrographolide in streptozotocin-induced diabetic rats.
December 2003, Planta medica,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats.
June 2010, Journal of natural products,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats.
August 2012, Journal of natural products,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of Fomitopsis pinicola extracts in streptozotocin-induced diabetic rats.
September 2008, Journal of medicinal food,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats.
January 2006, Journal of medicinal food,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats.
March 2012, Pharmaceutical biology,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of constituents from Hintonia standleyana in streptozotocin-induced diabetic rats.
December 2005, Planta medica,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats.
December 2006, Fitoterapia,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Oakmoss Exhibits Antihyperglycemic Activity in Streptozotocin-Induced Diabetic Rats.
March 2022, Cardiovascular & hematological disorders drug targets,
Feng-Lin Hsu, and I-Min Liu, and Daih-Huang Kuo, and Wang-Chuan Chen, and Hui-Chen Su, and Juei-Tang Cheng
Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
April 2016, Metabolic brain disease,
Copied contents to your clipboard!