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To identify the putative common deleted region on the long arm of chromosome 22 in pheochromocytoma, restriction fragment length polymorphism analysis was performed in 17 pheochromocytomas. All cases were heterozygous for at least one of the eight marker loci on 22q. Loss of heterozygosity (LOH) was observed in nine pheochromocytomas, of which eight were hereditary and one nonhereditary. Three pheochromocytomas had interstitial deletions that enabled us to localize the commonly deleted region as distal to D22S10 and proximal to D22S22. Hereditary pheochromocytoma frequently occurs in association with medullary thyroid carcinoma (MTC). Therefore, we also studied allelic loss on 22q in 23 hereditary MTCs. Only one of the MTCs showed LOH on 22q. Recent studies have mapped tumor suppressor loci associated with meningioma and neurofibromatosis type 2 (NF2) to 22q. The commonly deleted region in pheochromocytoma found by us encompasses the regions to which tumor suppressor genes associated with NF2 and meningioma have been mapped. The exact role of the pheochromocytoma tumor suppressor gene on 22q and its relationship to the suppressor genes involved in NF2 and meningioma remain unknown.
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
August 2002,
World journal of gastroenterology,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
August 2002,
World journal of surgery,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
September 1994,
British journal of cancer,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
July 1996,
Cancer research,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
April 2002,
Acta neuropathologica,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
February 1988,
Molecular biology & medicine,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
May 1993,
Hepatology (Baltimore, Md.),
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
October 1996,
Genes, chromosomes & cancer,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
March 2001,
Human pathology,
N Tanaka, and
I Nishisho, and
M Yamamoto, and
A Miya, and
E Shin, and
K Karakawa, and
S Fujita, and
T Kobayashi, and
G A Rouleau, and
T Mori
May 2003,
The Annals of thoracic surgery,
