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We have developed antibodies against the NK1 receptor and have investigated its cellular distribution. Rabbit polyclonal antibodies were generated against peptide (19-32) of the rat brain NK1 receptor. They were very specific to the NK1 site as shown by ELISA against various epitopes of NK1, NK2 and NK3 receptors and by immunoblotting of proteins from bacteria transfected with rat brain NK1 receptor cDNA and from rat cortex. Determining how immunostained NK1 receptors are distributed in the rat spinal cord made it possible to identify the cellular structures on which NK1 receptors are located and where they form synapses with SP terminals. In the superficial layers of the dorsal horn, the NK1 receptors appeared mainly of dendritic nature and were, like SP, abundant. In the deep layers of the dorsal horn and in the ventral horn, they were associated mostly with cell bodies.
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
January 2004,
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
July 1995,
European journal of pharmacology,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
September 1984,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
January 1987,
Archivum immunologiae et therapiae experimentalis,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
May 1992,
Journal of leukocyte biology,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
June 1997,
Neuroscience letters,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
February 1998,
Journal of neurochemistry,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
November 1989,
Molecular and cellular endocrinology,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
August 1997,
Neuroreport,
S M Moussaoui, and
E Hermans, and
A M Mathieu, and
B Bonici, and
F Clerc, and
F Guinet, and
C Garret, and
P M Laduron
January 1991,
Comparative biochemistry and physiology. A, Comparative physiology,
