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OBJECTIVE The objective of this study was to determine behavioural outcome and risk factors for abnormal behaviour at 2 y corrected age in very premature infants in a regionally defined, prospective cohort study. METHODS The Leiden Follow-Up Project on Prematurity includes all liveborn infants of < 32 wk gestational age, born in 1996/1997 (n = 266). Behaviour was assessed with the Child Behaviour Checklist 2-3. RESULTS An analysis of 158 questionnaires of 206 survivors (77%) was carried out. Fourteen children (9%) had a total problem score > p90 ("clinical range"). This percentage is comparable with the 10% found in a sample of 2- to 3-y-olds from the Dutch general population. Univariate analysis showed higher syndrome scale scores in one or more of the Child Behaviour Checklist scales in children of lower gestational age, small for gestational age (birthweight < p10), with neurological abnormalities at term or at 2 y and of non-Dutch origin. Lower socioeconomic status and postnatal treatment with dexamethasone were associated with higher scores in the somatic problems scale and lower maternal age at birth with a higher total problem score. After correction for confounding variables, the associations between small for gestational age, neurological abnormalities at 2 y and the anxious/depressed and/or withdrawn scales remained significant. CONCLUSIONS The prevalence of behavioural problems at 2 y corrected age in this cohort of very premature infants (gestational age < 32 wk) was comparable with that in a general population sample. Children born small for gestational age or with neurological abnormalities at 2 y of age had higher syndrome scale scores, mainly for anxious/depressed and/or withdrawn behaviour.
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
February 2008,
Pediatrics international : official journal of the Japan Pediatric Society,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
June 2019,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
December 2007,
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
January 2004,
The Clinical journal of pain,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
November 2020,
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
August 2022,
Andes pediatrica : revista Chilena de pediatria,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
May 2023,
Pediatric research,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
October 2019,
BMC pediatrics,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
September 2017,
Archives of disease in childhood. Fetal and neonatal edition,
G M S J Stoelhorst, and
S E Martens, and
M Rijken, and
P H T van Zwieten, and
A H Zwinderman, and
J M Wit, and
S Veen, and
July 2009,
Pediatrics,
