Biomaterial Database

Chemical synthesis of uridine diphospho-D-xylose and UDP-L-arabinose. 2003

Christiane Ernst, and Werner Klaffke

Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität, Corrensstrasse 40, D-48149 Münster, Germany.

Leloir transferases, like UDP-d-xylosyl transferase and arabinosyl transferase, utilize nucleoside diphosphate sugars to build up plant oligo- and polysaccharides. By the described, scalable three-step synthesis a simple route is described to arrive at the respective enzyme substrates, which are otherwise difficult to obtain.

UI	MeSH Term	Description	Entries
D013379	Substrate Specificity	A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.	Specificities, Substrate,Specificity, Substrate,Substrate Specificities
D014539	Uridine Diphosphate Sugars	Nucleotide-sugars such as uridine-diphosphate glucose or UDP-glucose.	UDP Sugars,Diphosphate Sugars, Uridine,Sugars, UDP,Sugars, Uridine Diphosphate
D014540	Uridine Diphosphate Xylose	The decarboxylation product of UDPglucuronic acid, which is used for formation of the xylosides of seryl hydroxyl groups in mucoprotein synthesis. Also forms plant xylans.	UDP Xylose,Diphosphate Xylose, Uridine,Xylose, UDP,Xylose, Uridine Diphosphate
D016695	Glycosyltransferases	Enzymes that catalyze the transfer of glycosyl groups to an acceptor. Most often another carbohydrate molecule acts as an acceptor, but inorganic phosphate can also act as an acceptor, such as in the case of PHOSPHORYLASES. Some of the enzymes in this group also catalyze hydrolysis, which can be regarded as transfer of a glycosyl group from the donor to water. Subclasses include the HEXOSYLTRANSFERASES; PENTOSYLTRANSFERASES; SIALYLTRANSFERASES; and those transferring other glycosyl groups. EC 2.4.	Glycosyltransferase,Glycoside Transferases,Transferases, Glycoside