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Carcinoembryonic antigen levels in peritoneal washes: a potential prognostic marker for patients with colorectal cancer. 2003

Nobutsugu Abe, and Takashi Watanabe, and Hiroshi Toda, and Hiromichi Machida, and Kazufumi Suzuki, and Tadahiko Masaki, and Masanori Sugiyama, and Yutaka Atomi, and Yuzo Nakaya
First Department of Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo 181-8611, Japan. abenbtg@kyorin-u.ac.jp

OBJECTIVE This study was conducted to define the clinical significance of intraoperative determination of carcinoembryonic antigen levels in peritoneal washes from patients undergoing surgery for colorectal cancer. METHODS The correlation of carcinoembryonic antigen levels in peritoneal washes (pCEA) with several clinicopathological factors and the long-term surgical outcome in 54 patients with resectable colorectal cancer was determined retrospectively. RESULTS Among several clinicopathological factors, the depth of tumor invasion significantly and independently correlated with pCEA levels as revealed by multivariate stepwise logistic regression analysis. A significant difference in overall survival rates was observed between pCEA-positive and pCEA-negative groups: five-year survival rates were 97.1% in pCEA-negative patients and 78.9% in pCEA-positive patients (p = 0.0274). CONCLUSIONS Intraoperative determination of carcinoembryonic antigen levels in peritoneal washes could be a potentially predictive factor of a poor prognosis in patients with colorectal cancer.

UI MeSH Term Description Entries
D007432 Intraoperative Period The period during a surgical operation. Intraoperative Periods,Period, Intraoperative,Periods, Intraoperative
D007507 Therapeutic Irrigation The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis. Douching,Lavage,Douchings,Irrigation, Therapeutic,Irrigations, Therapeutic,Lavages,Therapeutic Irrigations
D008207 Lymphatic Metastasis Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009361 Neoplasm Invasiveness Ability of neoplasms to infiltrate and actively destroy surrounding tissue. Invasiveness, Neoplasm,Neoplasm Invasion,Invasion, Neoplasm
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D001826 Body Fluids Liquid components of living organisms. Body Fluid,Fluid, Body,Fluids, Body
D002272 Carcinoembryonic Antigen A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment. Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D005260 Female Females

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