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Hemophilia A is an X-linked, recessive, bleeding disorder caused by defective or deficient factor VIII (FVIII) molecules. Infusion of purified FVIII to patients with severe hemophilia A results in approximately 25% of the cases, in the emergence of anti-FVIII antibodies (inhibitors) that are known to neutralize the pro-coagulant activity of FVIII by steric hindrance. We recently reported on the proteolysis of FVIII by allo-antibodies in the plasma of high responder patients with severe hemophilia A, demonstrating a new mechanism by which FVIII inhibitors may prevent the pro-coagulant function of FVIII. Hemophilia is the first model where a direct link between the hydrolysis of the target molecule and the occurrence of the clinical manifestations may be established. It also represents the first example in humans, of the induction of catalytic antibodies following the exogenous administration of an antigen. The characterization of FVIII inhibitors as site-specific proteases may provide new approaches to the treatment of inhibitors.
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
January 2000,
Chemical immunology,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
October 2000,
Haematologica,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
October 1982,
Thrombosis and haemostasis,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
October 1998,
Ugeskrift for laeger,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
February 2003,
Hamostaseologie,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
May 2006,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
September 1999,
Nature medicine,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
June 2003,
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis,
Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
February 1994,
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Jagadeesh Bayry, and
Sébastien Lacroix-Desmazes, and
Anastas Pashov, and
Dorothea Stahl, and
Johan Hoebeke, and
Michel D Kazatchkine, and
Srini V Kaveri
September 1986,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
