Autoreactive T cell responses in pemphigus and pemphigoid. 2002

Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
Department of Dermatology, University of Würzburg, Josef-Schneider Str. 2, 97080 Wurzburg, Germany.

Pemphigus and pemphigoid are cutaneous autoimmune diseases characterised by autoantibodies directed against specific adhesion proteins of the epidermis and dermal-epidermal junction. These proteins are usually associated with desmosomes or hemidesmosomes. Binding of antibodies to their targets leads to the loss of cell-cell or cell-matrix adhesion and subsequently to blister formation. The humoral aspects of the autoimmune responses in pemphigus and pemphigoid have been extensively studied in the past. More recently, the cellular interactions resulting in the formation of autoantibodies and the involvement of autoreactive T cells in these diseases have attracted increased interest. In this review, the current knowledge on T cell involvement in pemphigus and pemphigoid is summarised.

UI MeSH Term Description Entries
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D010391 Pemphigoid, Bullous A chronic and relatively benign subepidermal blistering disease usually of the elderly and without histopathologic acantholysis. Pemphigoid,Bullous Pemphigoid,Pemphigoids
D010392 Pemphigus Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS. Pemphigus Vulgaris,Pemphigus Foliaceus,Foliaceus, Pemphigus
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000938 Antigen-Presenting Cells A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. Accessory Cells, Immunologic,Antigen-Presenting Cell,Immunologic Accessory Cells,Accessory Cell, Immunologic,Cell, Immunologic Accessory,Cells, Immunologic Accessory,Immunologic Accessory Cell,Antigen Presenting Cell,Antigen Presenting Cells,Cell, Antigen-Presenting,Cells, Antigen-Presenting
D001324 Autoantigens Endogenous tissue constituents with the ability to interact with AUTOANTIBODIES and cause an immune response. Autoantigen,Autologous Antigen,Autologous Antigens,Self-Antigen,Self-Antigens,Antigen, Autologous,Antigens, Autologous,Self Antigen,Self Antigens
D013601 T-Lymphocytes Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen. T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D015551 Autoimmunity Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES. Autoimmune Response,Autoimmune Responses,Autoimmunities
D018448 Models, Immunological Theoretical representations that simulate the behavior or activity of immune system, processes, or phenomena. They include the use of mathematical equations, computers, and other electrical equipment. Immunological Models,Immunologic Model,Model, Immunologic,Immunologic Models,Immunological Model,Model, Immunological,Models, Immunologic

Related Publications

Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
January 1989, Autoimmunity,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
January 2021, Frontiers in immunology,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
April 2021, Italian journal of dermatology and venereology,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
December 1998, The Journal of clinical investigation,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
April 1991, International immunology,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
January 2022, Frontiers in immunology,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
April 1998, The Journal of investigative dermatology,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
July 2006, Neurochemistry international,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
December 2000, The British journal of dermatology,
Gertie J Oostingh, and Cassian Sitaru, and Arno Kromminga, and Dirk Dormann, and Detlef Zillikens
July 2001, Nature medicine,
Copied contents to your clipboard!