BIOMAT Database Logo BIOMAT Database Logo

Granulovacuolar degeneration in the hippocampal cortex of aging and demented patients--a quantitative study. 1992

M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Department of Psychiatry, Nagoya University School of Medicine, Japan.

The occurrence and topographic analysis of granulovacuolar degeneration (GVD) in the hippocampal cortex of mentally normal controls (75 cases) and patients with Alzheimer's dementia (AD; 17 cases which included Alzheimer's disease and senile dementia of Alzheimer type), multi-infarct dementia (MID; 16 cases), Pick's disease (PD; 5 cases) and atypical dementia [5 cases; non-Alzheimer, non-Pick dementia with Fahr's syndrome (NANPDF)] were investigated. GVD was rarely found in control cases below the age of 60 years. In elderly normal brains, the statistically most representative ranking order of predilection for GVD (in decreasing severity) was: in the 60 s, CA1 > prosubiculum > CA2 (no GVD was found in the CA3 and CA4); in the 70 s, CA1 > prosubiculum > CA2 > CA3 > CA4; in the 80 s, CA1 > prosubiculum > CA2 > CA3 > CA4; in the 90 s, CA1 > prosubiculum > CA2 > CA3 > CA4. In the brains of demented patients, the rank order for GVD was: for AD, CA1 > CA2 > CA3 > prosubiculum > CA4; for MID, CA1 > prosubiculum > CA2 > CA3 > CA4; for PD, CA1 > CA2 > CA3 > prosubiculum > CA4; and for atypical dementia (NANPDF), CA1 > CA2 > prosubiculum > CA3 > CA4. The similarity of the predilection to ranking order was noted both in normal aged subjects and in MID as well as both in AD and in PD.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009410 Nerve Degeneration Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. Neuron Degeneration,Degeneration, Nerve,Degeneration, Neuron,Degenerations, Nerve,Degenerations, Neuron,Nerve Degenerations,Neuron Degenerations
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D003704 Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. Senile Paranoid Dementia,Amentia,Familial Dementia,Amentias,Dementia, Familial,Dementias,Dementias, Familial,Dementias, Senile Paranoid,Familial Dementias,Paranoid Dementia, Senile,Paranoid Dementias, Senile,Senile Paranoid Dementias
D005260 Female Females
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of aging and demented patients. A quantitative study.
May 1978, Acta neuropathologica,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Granulovacuolar degeneration of hippocampal pyramidal cells.
March 1972, The Journal of pathology,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Granulovacuolar Degeneration in Hippocampus of Neurodegenerative Diseases: Quantitative Study.
January 2016, Journal of neurodegenerative diseases,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Relationship of granulovacuolar degeneration in hippocampal neurones to aging and to dementia in normal-pressure hydrocephalics.
November 1978, Journal of gerontology,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study.
February 1977, Acta neuropathologica,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Reexamination of granulovacuolar degeneration.
January 1991, Acta neuropathologica,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
December 2011, Laboratory investigation; a journal of technical methods and pathology,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Granulovacuolar degeneration in pyramidal cells of the hippocampus.
May 1978, Acta neuropathologica,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Relation of hippocampal phospho-SAPK/JNK granules in Alzheimer's disease and tauopathies to granulovacuolar degeneration bodies.
January 2007, Acta neuropathologica,
M Xu, and H Shibayama, and H Kobayashi, and K Yamada, and R Ishihara, and P Zhao, and T Takeuchi, and K Yoshida, and T Inagaki, and K Nokura
Granulovacuolar degeneration in the ageing brain and in dementia.
May 1977, Journal of neuropathology and experimental neurology,
Copied contents to your clipboard!