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The distribution of HLA-A, B, C, DR and DRB1, DQB1, DPB1 alleles was studied in 60 Japanese patients with clinically definite multiple sclerosis (MS) using serologic and genomic analysis. We found significant associations with HLA-Cw3 (p = 0.002, pc = 0.012, RR = 3.2), DR2 (p = 0.007, RR = 2.6), and DQB1*0602 (p = 0.04, RR = 4.0) in Japanese patients for the first time. The combined presence of Cw3 and DR2 gave a higher risk than each antigen alone. The reported increase in the frequency of DPw4 in Japanese MS patients [12] could not be confirmed by our genomic study. The frequencies of all of the residues in each variable region of the amino acid sequences of DQ beta and DP beta chains were not different between the MS patients and the controls. These results suggest that MS susceptibility may result from polygenic influences and from the presence of environmental factors.
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
February 2009,
Cellular and molecular neurobiology,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
January 2021,
Iranian journal of child neurology,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
June 1997,
Neurology,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
October 2015,
Archives of Iranian medicine,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
January 1992,
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
April 1991,
Tissue antigens,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
December 2000,
The Journal of rheumatology,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
September 2009,
Journal of immunology (Baltimore, Md. : 1950),
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
December 2003,
Arquivos de neuro-psiquiatria,
Q Hao, and
T Saida, and
H Kawakami, and
H Mine, and
E Maruya, and
H Inoko, and
H Saji
October 2007,
Journal of internal medicine,
