BIOMAT Database Logo BIOMAT Database Logo

Imipenem and cefotaxime resistance: transduction by wild-type phages in hospital strains of Pseudomonas aeruginosa. 1992

J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Institute of Preventive and Clinical Medicine, Bratislava, Czecho-Slavakia.

A wild-type bacteriophage appeared and was isolated from a Pseudomonas aeruginosa strain resistant to imipenem, cefotaxime, kanamycin and streptomycin (susceptible to carbenicillin, aztreonam, amikacin and fluoroquinolones). The best transducing properties were obtained with phage lysates prepared from bacteria growing on cefotaxime or imipenem. Transducing properties were found specific for individual recipient strain(s) susceptible to all drugs. A high-frequency of transduction was recorded for kanamycin and particularly for cefotaxime resistance determinants, followed by an imipenem determinant. This is now the fourth published wild-type bacteriophage, isolated from lysogenic nosocomial P. aeruginosa resistant to imipenem which was found to transduce this resistance determinant to susceptible pseudomonads.

UI MeSH Term Description Entries
D011550 Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection. Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D002439 Cefotaxime Semisynthetic broad-spectrum cephalosporin. Benaxima,Biosint,Cefotaxim,Cefotaxime Sodium,Cefradil,Cephotaxim,Claforan,Fotexina,HR-756,Kendrick,Klaforan,Primafen,Ru-24756,Taporin,HR 756,HR756,Ru 24756,Ru24756,Sodium, Cefotaxime
D004352 Drug Resistance, Microbial The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D014161 Transduction, Genetic The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE. Genetic Transduction,Genetic Transductions,Transductions, Genetic
D015378 Imipenem Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor. Imipemide,N-Formimidoylthienamycin,Imipenem Anhydrous,Imipenem, Anhydrous,MK-0787,MK0787,Anhydrous Imipenem,Anhydrous, Imipenem,MK 0787,N Formimidoylthienamycin
D017105 Pseudomonas Phages Viruses whose host is Pseudomonas. A frequently encountered Pseudomonas phage is BACTERIOPHAGE PHI 6. Pseudomonas Bacteriophages,Bacteriophage, Pseudomonas,Bacteriophages, Pseudomonas,Pseudomonas Bacteriophage,Pseudomonas Phage

Related Publications

J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Transduction of antibiotic resistance including imipenem resistance by wild type phages from nosocomial strains of Pseudomonas aeruginosa.
October 1997, Acta virologica,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Transduction of imipenem resistance by wild-type bacteriophages carried by three strains of Pseudomonas aeruginosa isolated from a single source.
June 1998, The Journal of antimicrobial chemotherapy,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Ceftazidime resistance in Pseudomonas aeruginosa: transduction by a wild-type phage.
December 1986, The Journal of infectious diseases,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Mechanism of imipenem resistance acquired by three Pseudomonas aeruginosa strains during imipenem therapy.
August 1990, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
[Imipenem resistance in Pseudomonas aeruginosa].
October 1998, Wiener klinische Wochenschrift,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
[Imipenem resistance in Pseudomonas aeruginosa].
November 1986, Immunitat und Infektion,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Imipenem resistance in Pseudomonas aeruginosa.
January 1991, Antibiotics and chemotherapy,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
High-frequency transduction of antibiotic resistance in Pseudomonas aeruginosa by a wild-type bacteriophage with restricted specificity for recipient strains.
February 1999, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Resistance to imipenem in Pseudomonas aeruginosa.
December 1995, The Journal of antimicrobial chemotherapy,
J Blahová, and M Hupková, and V Krcméry, and V Schäfer
Transferable imipenem resistance in Pseudomonas aeruginosa.
January 1991, Antimicrobial agents and chemotherapy,
Copied contents to your clipboard!