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Oxotremorine did not alter the level of 5-HT and 5-hydroxyindoleacetic acid in different brain regions. The content of 5-HT in the striatum was diminished by electrolytic lesions of the raphe system, by microinjection of the selective depletor 5,6-dihydroxytryptamine into the raphe system and inhibition of synthesis by pCPA or pCAM. The intensity of oxotremorine-induced tremor was reduced only in some experimental groups without clear-cut correlation to the decreased 5-HT levels. In pCPA-pretreated animals resoring of 5-HT concentration by intrastriatal microinjection of 5-HT and ip administration of 5-HT did not reestablish tremor intensity. There is no evidence that cholinergic tremor is triggered indirectly and depends upon an intact 5-HT system.
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
January 1998,
Acta medica (Hradec Kralove),
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
July 1971,
British journal of industrial medicine,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
July 1992,
Journal of biomedical engineering,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
November 1964,
Pathologie et biologie,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
August 1971,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
April 1972,
Archives internationales de pharmacodynamie et de therapie,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
October 1971,
Lakartidningen,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
January 1993,
Clinical pharmacology and therapeutics,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
January 1973,
Annual review of pharmacology,
W Oelszner, and
K F Funk, and
A H Staib, and
K H Westermann
January 1969,
Federation proceedings,
