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In 2K,1C-RHR (two-kidney, one-clip hypertensive rats) serotonergic mechanisms in blood platelets were studied. The endogenous serotonin (5-HT) concentration in whole blood and in platelets remained unchanged in relation to the sham operated rats. Also the uptake of labelled 5-HT in rats with renal hypertension was not altered. However platelets aggregability was increased in 2K,1C-RHR. Acute administration of captopril (10 mg/kg and 100 mg/kg po) diminished blood pressure but did not change either the concentration of 5-HT in whole blood and in platelets of hypertensive rats or the uptake of this amine. Platelets aggregation and the amplifying effect of 5-HT in hypertensive rats were also unchanged after acute captopril administration. Similar results were observed after its administration in a dose of 30 mg/kg for one week. Our results indicate that captopril did not affect the platelets serotonergic mechanisms in 2K,1C-RHR.
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
January 1995,
Polish journal of pharmacology,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
February 1983,
Chest,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
January 1983,
Clinical and experimental hypertension. Part A, Theory and practice,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
January 1993,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
August 1986,
The American journal of physiology,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
January 1983,
Pflugers Archiv : European journal of physiology,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
August 1997,
European journal of pharmacology,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
August 1986,
Neuroscience letters,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
January 1984,
Clinical and experimental hypertension. Part A, Theory and practice,
D Morelowska, and
E Chabielska, and
D Pawlak, and
A Azzadin, and
A Białkowska, and
D Krygicz, and
W Buczko
September 1997,
Hypertension (Dallas, Tex. : 1979),
