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Synthesis of PNA using a Fmoc/Boc protecting group strategy. 2002

Toru Sugiyama, and Atsushi Kittaka, and Yohei Takemoto, and Hiroaki Takayama, and Reiko Kuroda
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.

Syntheses of PNA monomers whose nucleobases are protected with Boc group are described. To overcome the solubility problem of carboxymethyl-guanine derivative, we introduced 2-trimethylsilylethyl group at O6 as a second protecting group.

UI MeSH Term Description Entries
D005449 Fluorenes A family of diphenylenemethane derivatives.
D020135 Peptide Nucleic Acids DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers. Peptide Nucleic Acid,Acid, Peptide Nucleic,Acids, Peptide Nucleic,Nucleic Acid, Peptide,Nucleic Acids, Peptide

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