BIOMAT Database Logo BIOMAT Database Logo

Monitoring response to antiviral therapy for patients with chronic hepatitis C virus infection by a core-antigen assay. 2003

Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Laboratori di Ricerca-Area Infettivologica, Servizio di Virologia, IRCCS Policlinico San Matteo and Università degli Studi di Pavia, Pavia, Italy.

A recently released immunoassay detecting total serum hepatitis C virus (HCV) core antigen was used to prospectively monitor virological responses to antiviral treatment in patients with chronic HCV infection. Sustained responders cleared core protein from serum within the first month of therapy and maintained stably negative values for the entire duration of follow-up after treatment discontinuation. However, patients who relapsed or failed to respond showed transient negative values and could not be accurately discriminated either because of the intrinsic lower sensitivity of the core-antigen assay than those of molecular assays or because of differentially regulated secretion of immunoreactive core protein from infected hepatocytes.

UI MeSH Term Description Entries
D007118 Immunoassay A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance. Immunochromatographic Assay,Assay, Immunochromatographic,Assays, Immunochromatographic,Immunoassays,Immunochromatographic Assays
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D012367 RNA, Viral Ribonucleic acid that makes up the genetic material of viruses. Viral RNA
D016174 Hepacivirus A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species. Hepatitis C virus,Hepatitis C-Like Viruses,Hepaciviruses,Hepatitis C Like Viruses,Hepatitis C viruses,Hepatitis C-Like Virus
D016903 Drug Monitoring The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically. Monitoring, Drug,Therapeutic Drug Monitoring,Drug Monitoring, Therapeutic,Monitoring, Therapeutic Drug
D018936 Hepatitis C Antigens Antigens of the virions of HEPACIVIRUS, their surface, core, or other associated antigens. Hepatitis C Antigen,Hepatitis Non-A, Non-B Antigen,Hepatitis Non A, Non B Antigen
D019698 Hepatitis C, Chronic INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS. Chronic Hepatitis C

Related Publications

Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Monitoring treatment response by the hepatitis C virus core antigen assay.
March 2005, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Monitoring response to antiviral treatment by serum hepatitis C virus core antigen: too early to take shortcuts?
March 2004, Journal of hepatology,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Isolated antibody to hepatitis B core antigen in patients with chronic hepatitis C virus infection.
July 2006, World journal of gastroenterology,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Antiviral treatment responses in patients with chronic hepatitis C virus infection evaluated by a third generation anti-hepatitis C virus assay.
July 2002, Journal of viral hepatitis,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C.
September 2016, Journal of Korean medical science,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Quantitative determination of hepatitis C core antigen in therapy monitoring for chronic hepatitis C.
February 2011, Intervirology,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Clinical utility of hepatitis C virus core antigen assay in the monitoring of direct-acting antivirals for chronic hepatitis C.
January 2020, PloS one,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Quantification of Core Antigen Monitors Efficacy of Direct-acting Antiviral Agents in Patients With Chronic Hepatitis C Virus Infection.
September 2016, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Occult hepatitis B virus infection in patients with chronic hepatitis C treated with antiviral therapy.
November 2012, Hepatitis monthly,
Chiara Rebucci, and Antonella Cerino, and Agostino Cividini, and Letizia Timo, and Milena Furione, and Mario U Mondelli
Hepatitis C core antigen: Diagnosis and monitoring of patients infected with hepatitis C virus.
December 2019, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,
Copied contents to your clipboard!