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The present study reveals the inhibitory effect of iron intoxication on the process of dentine mineralization. Wistar rats were injected intraperitoneally with iron dextran at 0.88 g/kg body weight per day for 10 days during the period of odontogenesis. An age-matched group was injected intraperitoneally with bisodium etidronate (EHBP) at 20 mg/kg body weight per day for 10 days. Another age-matched group was treated with similar amounts of saline intraperitoneally and considered as control. At the end of the experimental period the animals intoxicated with iron exhibited non-mineralized dentine and mineralized bone. The animals treated with EHBP showed non-mineralized dentine and bone. These findings would suggest the existence of different mineralization mechanisms for bone and dentine.
R C De Lucca, and
P M Mandalunis, and
A M Ubios
January 1997,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
July 1966,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
January 1969,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
February 1960,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
November 1960,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
January 1993,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
November 1960,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
January 1979,
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R C De Lucca, and
P M Mandalunis, and
A M Ubios
April 2014,
Clinical oral investigations,
