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Chromoendoscopy with methylene blue has been proposed to improve targeting of biopsies to specialised intestinal metaplasia and dysplasia in Barrett's oesophagus. However, methylene blue can induce oxidative damage of DNA when photosensitised by white light. We show that damage to DNA is increased in Barrett's mucosa after chromoendoscopy with methylene blue, an effect apparently dependent on presence of both methylene blue and endoscopic white light. Exposure of Barrett's mucosa to DNA damage during endoscopy warrants caution since it could accelerate carcinogenesis. This risk needs to be carefully balanced against the possible benefit of improved early detection of preneoplastic lesions with methylene blue chromoendoscopy.
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
January 2003,
Arquivos de gastroenterologia,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
September 2001,
Gastrointestinal endoscopy,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
March 2008,
Surgical endoscopy,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
September 2001,
Gastrointestinal endoscopy,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
May 2003,
Endoscopy,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
January 2013,
Revista de gastroenterologia de Mexico,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
May 2009,
Mutagenesis,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
January 2001,
Gastrointestinal endoscopy,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
May 2006,
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
J R Olliver, and
C P Wild, and
P Sahay, and
S Dexter, and
L J Hardie
November 2001,
Gastrointestinal endoscopy,
