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Bone marrow necrosis and human parvovirus associated infection preceding an Ph1+ acute lymphoblastic leukemia. 1992
T Petrella, and
F Bailly, and
F Mugneret, and
D Caillot, and
P Chavanet, and
H Guy, and
E Solary, and
A Waldner, and
E Devilliers, and
P M Carli
Department of Pathology, Faculty of Medicine, Dijon, France.
A case of bone marrow necrosis associated with a serologically documented recent Parvovirus B 19 infection which preceded the development of PH1+ acute lymphoblastic leukemia is reported. No conclusions can be drawn on the basis of a single case but the question of the role of human Parvovirus B19 in the pathogenesis of bone marrow necrosis is discussed. It is suggested that the virus may act as a co-factor for the induction of bone marrow necrosis, in some cases.
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