BIOMAT Database Logo BIOMAT Database Logo

Secondary rifampin resistance following multi-drug therapy--a case report. 2003

Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Department of Community Health, Schieffelin Leprosy Research and Training Center, Karigiri, Vellore-632106, India. oculep@vsnl.com

This is the first report of secondary resistance to rifampin following MDT in a patient with prolonged, but irregular treatment. Repeated mouse foot-pad studies demonstrated resistance to dapsone after several years of monotherapy, and following subsequent MDT the studies demonstrated the development of resistance to rifampin.

UI MeSH Term Description Entries
D007917 Leprostatic Agents Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions. Antileprotic Agents,Leprostatics,Agents, Antileprotic,Agents, Leprostatic
D007918 Leprosy A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid. Hansen's Disease,Hansen Disease
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003622 Dapsone A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) Diaminodiphenylsulfone,Sulfonyldianiline,4,4'-Diaminophenyl Sulfone,Avlosulfone,DADPS,Dapsoderm-X,Dapson-Fatol,Diaphenylsulfone,Disulone,Sulfona,4,4' Diaminophenyl Sulfone,Sulfone, 4,4'-Diaminophenyl
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012293 Rifampin A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) Rifampicin,Benemycin,Rifadin,Rimactan,Rimactane,Tubocin
D018432 Drug Resistance, Multiple Simultaneous resistance to several structurally and functionally distinct drugs. Drug Resistance, Extensively,Extensively Drug Resistance,Extensively-Drug Resistance,Multidrug Resistance,Multi-Drug Resistance,Extensively Drug Resistances,Extensively-Drug Resistances,Multiple Drug Resistance,Resistance, Extensively Drug,Resistance, Extensively-Drug,Resistance, Multiple Drug
D024881 Drug Resistance, Bacterial The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance, Bacterial,Antibacterial Drug Resistance

Related Publications

Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Colistin, meropenem and rifampin in a combination therapy for multi-drug-resistant Acinetobacter baumannii multifocal infection. A case report.
March 2007, Minerva anestesiologica,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Rifampin - Risperidone and Divalproex Drug-drug Interaction: A Case Report.
May 2023, Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Drug interaction between rifampin and nortriptyline: a case report.
January 1991, International journal of psychiatry in medicine,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Secondary venous aneurysm following intravenous drug abuse: A case report.
May 2016, Vojnosanitetski pregled,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Rifampin-divalproex drug-drug interaction in an adult patient: A case report.
January 2021, The mental health clinician,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Severe Xerostomia Secondary to Anticholinergic Drug Therapy: Case Report.
February 2017, Dentistry today,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Bioactive Glass in a Multi Drug Resistance Osteomyelitis in Diabetic Foot: Case Report.
May 2022, The international journal of lower extremity wounds,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Drug resistance and multi-drug therapy in leprosy.
July 1989, Indian journal of leprosy,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Drug resistance and multi-drug therapy in leprosy.
July 1982, Leprosy in India,
Gift Norman, and Geetha Joseph, and Gigi Ebenezer, and Sundar P Rao, and Charles K Job
Multi-drug resistant Klebsiella-induced corneal ulcer following pterygium surgery: a case report.
April 2023, BMC ophthalmology,
Copied contents to your clipboard!