Biomaterial Database

[Effect of hypoxia on respiration system in aging]. 2003

O V Korkushko, and L A Ivanov, and M D Chebotar'ov, and A V Pysaruk

Institute of Gerontology AMS of Ukraine, Kiev.

The purpose of the research was to investigate the peculiarities of ventilatory reaction to hypoxia with the elderly and old people. 27 practically healthy young (20-35 years), 24 elderly (60-74 years) and old (older 74 years) people were examined. The influence of hypoxia on the gas exchange was investigated during the respiration of gas mixtures with 17% and 12.5% of oxygen content (during 12 minutes), that corresponds to 1500 m and 4000 m above sea level. The parameters of ventilating function of the lung were determined on the spirograf CT-1M. Oxygen tension in arterial blood (PaO2) was determined with the device "AVL" by "OMNI" (Austria). The curves of ventilating dependence on PaO2 for the young and old people are plotted using the mathematical model. It was shown, that with aging the "steepness" of curve's dependence on the ventilatory answer from the degree of hypoxemia decreases, that testifies to the decrease of chemoreflex sensitivity.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010092	Oximetry	The determination of oxygen-hemoglobin saturation of blood either by withdrawing a sample and passing it through a classical photoelectric oximeter or by electrodes attached to some translucent part of the body like finger, earlobe, or skin fold. It includes non-invasive oxygen monitoring by pulse oximetry.	Pulse Oximetry,Oximetry, Pulse,Oximetries,Oximetries, Pulse,Pulse Oximetries
D010100	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.	Dioxygen,Oxygen-16,Oxygen 16
D012123	Pulmonary Ventilation	The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.	Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D000375	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	Senescence,Aging, Biological,Biological Aging
D000860	Hypoxia	Sub-optimal OXYGEN levels in the ambient air of living organisms.	Anoxia,Oxygen Deficiency,Anoxemia,Deficiency, Oxygen,Hypoxemia,Deficiencies, Oxygen,Oxygen Deficiencies