-transparent.png){kind=logo}
Acute renal denervation (DNX) has been reported to increase urinary phosphate (Pi) excretion in rats with intact parathyroid glands and also in rats which were thyroparathyroidectomized (TPTX). The present study was performed to determine the effects of acute renal denervation on the tubular transport of Pi in rats in the absence of parathyroid hormone (PTH) and in rats with constant PTH levels. In TPTX rats, the reabsorbed Pi normalized for the glomerular filtration rate (Reab Pi/GFR) was 2.38 +/- 0.16 mumol/ml in the DNX kidney compared to 2.56 +/- 0.16 mumol/ml (p < 0.05) in the contralateral innervated (INN) kidney at endogenous plasma phosphate levels (n = 6). The lower values for the Reab Pi/GFR in the DNX kidney persisted at elevated plasma phosphate concentrations during phosphate infusions. Infusion of PTH resulted in markedly lower Reab Pi/GFR values in the innervated kidney (1.47 +/- 0.21 mumol/ml) at endogenous plasma phosphate levels than in the vehicle-infused group. Furthermore, the Reab Pi/GFR in the DNX kidney was decreased (1.21 +/- 0.14 mumol/ml, n = 6) compared to the contralateral INN kidney. These studies demonstrate that acute renal DNX decreases the tubular transport of Pi both in the absence and in the presence of constant PTH levels.
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
September 1983,
The American journal of physiology,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
August 1985,
The American journal of physiology,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
January 2012,
Kidney & blood pressure research,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
January 1978,
Advances in experimental medicine and biology,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
January 1977,
The American journal of physiology,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
January 1978,
The American journal of physiology,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
January 1988,
Pediatric nephrology (Berlin, Germany),
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
February 1965,
Clinica chimica acta; international journal of clinical chemistry,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
August 1969,
Clinical science,
K J Mann, and
D M Dousa, and
R J Kerrigan, and
T J Berndt, and
F G Knox
August 2008,
The New England journal of medicine,
